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Most models for transcription and replication involve polymerases that track along the template. We review here experiments that suggest an alternative in which polymerization occurs as the template slides past a polymerase fixed to a large structure in the eukaryotic nucleus--a "factory" attached to a nucleoskeleton. This means that higher-order structure dictates how and when DNA is replicated or transcribed.


Journal article


Int Rev Cytol

Publication Date





125 - 149


Animals, Cell Nucleus, Chromatin, DNA-Directed DNA Polymerase, DNA-Directed RNA Polymerases, Humans, Nuclear Matrix, Protein Conformation