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Transplantation tolerance can be induced by a range of agents that block T cell/antigen-presenting cell (APC) interactions known to be important for initiation of the adaptive immune response. Tolerance so induced has been shown to have a regulatory phenotype dependent on CD4+ cells. This was first observed with nonlytic anti-CD4 antibodies, and was recently demonstrated following other therapeutic approaches. Dominant tolerance also plays a role in natural regulation of the immune response, functioning to prevent autoaggressive cells mediating self-destruction. The mechanism by which dominant tolerance is established and maintained remains unclear, and the reported characteristics of regulatory cells in different experimental models vary widely. Here we review the evidence for potential mechanisms involved and propose that there is a common pathway by which dominant tolerance is mediated.

Original publication

DOI

10.1007/BF02786503

Type

Journal article

Journal

Immunol Res

Publication Date

1999

Volume

20

Pages

1 - 14

Keywords

Antibodies, Monoclonal, Antigen-Presenting Cells, CD4-Positive T-Lymphocytes, Clonal Anergy, Immune Tolerance, Models, Immunological, T-Lymphocytes, Helper-Inducer, Transplantation Immunology