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Thirty patients were examined to test the hypothesis that a depletion of iron levels is associated with symptoms of akathisia. Fifteen akathisic patients were pair-matched with 15 non-akathisic patients. Plasma ferritin levels were significantly decreased in the akathisic patients, and there was a significant inverse correlation between plasma iron levels and akathisia rating. In addition, akathisia ratings were found to be correlated with a scale measuring symptoms of tardive dyskinesia.


Journal article


J Neurol Neurosurg Psychiatry

Publication Date





671 - 674


Adult, Akathisia, Drug-Induced, Anemia, Hypochromic, Antipsychotic Agents, Carrier Proteins, Dose-Response Relationship, Drug, Dyskinesia, Drug-Induced, Female, Ferritins, Humans, Iron, Iron-Binding Proteins, Male, Middle Aged, Psychomotor Agitation, Risk Factors, Transferrin-Binding Proteins