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Our understanding of tolerance mechanisms has progressed to the point that tolerance-induction protocols are being tested in humans for organ transplantation. However, a range of scientific, ethical, logistic and commercial issues have arisen, and must be resolved before tolerance induction for human allograft patients can become a reality.

Original publication

DOI

10.1038/15197

Type

Journal article

Journal

Nat Med

Publication Date

11/1999

Volume

5

Pages

1245 - 1248

Keywords

Adaptation, Physiological, Animals, Humans, T-Lymphocytes, Transplantation Immunology