Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Memory or antigen-experienced CD4 T cells differ from naive CD4 T cells both phenotypically by cell surface marker expression, and functionally by their dissimilar pattern of cytokine secretion and activation requirements through their T cell receptor (TCR). We show here that activation of memory CD4 T cells (CD45RBlo subset), but not naive CD4 T cells (CD45RBhi subset), is inhibited by MHC class II molecules on antigen-presenting cells and by CD4 ligation. We propose that the selective negative signal in memory cells is a direct result of the differences in signaling via CD4 and CD3, exemplified in the disparate pattern of tyrosine-phosphorylated proteins visible after activation of the two subsets. In vivo, this inhibitory signal may serve to prevent irrelevant interactions between memory CD4 T cells and bystander MHC class II+ cells, and may also be responsible for the defective functioning of memory CD4 T cells in AIDS.

Type

Journal article

Journal

Immunity

Publication Date

03/1995

Volume

2

Pages

249 - 259

Keywords

Animals, Antigen-Presenting Cells, Antigens, CD3, Antigens, CD4, Antigens, CD45, CD4-Positive T-Lymphocytes, Female, Histocompatibility Antigens Class II, Immunologic Memory, Interferon-gamma, Interleukin-4, L Cells (Cell Line), Lymphocyte Activation, Mice, Mice, Inbred BALB C, Phosphotyrosine, Signal Transduction, Tyrosine