The effect of robenacoxib on the concentration of C-reactive protein in synovial fluid from dogs with osteoarthritis.
Bennett D., Eckersall PD., Waterston M., Marchetti V., Rota A., McCulloch E., Sbrana S.
BACKGROUND: Robenacoxib is a novel and highly selective inhibitor of COX-2 in dogs and cats and because of its acidic nature is regarded as being tissue-selective. Thirty four dogs with stifle osteoarthritis secondary to failure of the cranial cruciate ligament were recruited into this study. Lameness, radiographic features, synovial cytology and C-reactive protein concentrations in serum and synovial fluid were assessed before and 28 days after commencing a course of Robenacoxib at a dose of 1 mg/kg SID. RESULTS: There was a significant reduction in the lameness score (P