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A new monoclonal rat anti-human lymphocyte antibody (CAMPATH-1) which lyses cells with autologous human complement was used for depletion of T lymphocytes from human bone-marrow allografts in vitro before transplantation in 11 high-risk patients. HLA-matched siblings were used as marrow donors. T-cell depletion was substantial when measured by E-rosette formation (0-0.18% residual T cells) and immunofluorescence with a monoclonal anti-T-cell antibody (0-0.5%). No anti-graft-versus-host disease prophylaxis was given after transplantation. Rapid engraftment was reported in all patients, and the post-transplantation course was uneventful. No signs of graft-versus-host disease developed in any of the patients, who were observed for a maximum period of 12 months. The method might be suitable for larger-scale studies in high-risk patients. The late graft failure seen in 2 patients may reflect residual host resistance uncompromised by GvHD.

Type

Journal article

Journal

Lancet

Publication Date

01/09/1984

Volume

2

Pages

483 - 486

Keywords

Adolescent, Adult, Animals, Antibodies, Monoclonal, Bone Marrow Transplantation, Child, Child, Preschool, Female, Graft vs Host Disease, Humans, Infant, Lymphocyte Depletion, Lymphocytes, Male, Methods, Prospective Studies, Rats