Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Pathogenic repeat sequences underlie several human disorders, including amyotrophic lateral sclerosis, Huntington's disease, and myotonic dystrophy. Here, we speak to several researchers about how repeat sequences have been implicated in affecting all aspects of the Central Dogma of molecular biology through their effects on DNA, RNA, and protein.

Original publication

DOI

10.1016/j.molcel.2022.12.017

Type

Journal article

Journal

Mol Cell

Publication Date

02/02/2023

Volume

83

Pages

324 - 329

Keywords

Humans, Amyotrophic Lateral Sclerosis, Proteins, Huntington Disease, RNA, Myotonic Dystrophy, Trinucleotide Repeat Expansion