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The cell division cycle ensures that chromosomal DNA is replicated completely and that it is subsequently segregated into daughter cells. Genes responsible for the accurate execution of every aspect of this cycle have been identified in a wide variety of bacterial, archeal, and eukaryotic species. The combination of classical and molecular genetic studies with biochemistry and microscopy has generated a coherent overview of cell-cycle controls, which in many key respects have been highly conserved during evolution.

Original publication





Book title

Brenner's Encyclopedia of Genetics: Second Edition

Publication Date



467 - 469