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Autoantibodies against the extracellular domain of the N-methyl-d-aspartate receptor (NMDAR) NR1 subunit cause a severe and common form of encephalitis. To better understand their generation, we aimed to characterize and identify human germinal centres actively participating in NMDAR-specific autoimmunization by sampling patient blood, CSF, ovarian teratoma tissue and, directly from the putative site of human CNS lymphatic drainage, cervical lymph nodes. From serum, both NR1-IgA and NR1-IgM were detected more frequently in NMDAR-antibody encephalitis patients versus controls (both P 

Original publication

DOI

10.1093/brain/awac088

Type

Journal article

Journal

Brain

Publication Date

24/03/2022

Keywords

NMDAR-antibody encephalitis, brain autoimmunity, cervical lymph node, germinal centre, teratoma