Diurnal modulation of subthalamic beta oscillatory power in Parkinson's disease patients during deep brain stimulation.
van Rheede JJ., Feldmann LK., Busch JL., Fleming JE., Mathiopoulou V., Denison T., Sharott A., Kühn AA.
Beta-band activity in the subthalamic local field potential (LFP) is correlated with Parkinson's disease (PD) symptom severity and is the therapeutic target of deep brain stimulation (DBS). While beta fluctuations in PD patients are well characterized on shorter timescales, it is not known how beta activity evolves around the diurnal cycle, outside a clinical setting. Here, we obtained chronic recordings (34 ± 13 days) of subthalamic beta power in PD patients implanted with the Percept DBS device during high-frequency DBS and analysed their diurnal properties as well as sensitivity to artifacts. Time of day explained 41 ± 9% of the variance in beta power (p