Appropriate targets for monoclonal antibodies in the induction of transplantation tolerance.
Waldmann H., Hale G., Cobbold S.
There are many routes to exploiting tolerance processes to ensure long-term graft survival. Complete tolerance although attractive as a goal, may not be the most practical in the clinic. Instead simple and low-impact procedures that harness tolerance processes used in conjunction with low doses of immunosuppressive drugs may prove the most reliable and user-friendly of approaches.