Common variants contribute to intrinsic human brain functional networks.
Zhao B., Li T., Smith SM., Xiong D., Wang X., Yang Y., Luo T., Zhu Z., Shan Y., Matoba N., Sun Q., Yang Y., Hauberg ME., Bendl J., Fullard JF., Roussos P., Lin W., Li Y., Stein JL., Zhu H.
The human brain forms functional networks of correlated activity, which have been linked with both cognitive and clinical outcomes. However, the genetic variants affecting brain function are largely unknown. Here, we used resting-state functional magnetic resonance images from 47,276 individuals to discover and validate common genetic variants influencing intrinsic brain activity. We identified 45 new genetic regions associated with brain functional signatures (P