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The traditional model for transcription sees active polymerases tracking along their templates. An alternative (controversial) model has active enzymes immobilized in "factories." Recent evidence supports the idea that the DNA moves, not the polymerase, and points to alternative explanations of how regulatory motifs like enhancers and silencers work.

Original publication

DOI

10.4161/trns.2.1.14275

Type

Journal article

Journal

Transcription

Publication Date

01/2011

Volume

2

Pages

41 - 44

Keywords

chromatin loops, fixed RNA polymerases, nuclear organization, transcription factories, Animals, DNA, DNA-Directed RNA Polymerases, Gene Expression Regulation, Humans, Models, Genetic, Templates, Genetic, Transcription, Genetic