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The Polycomb repressive system functions through chromatin to regulate gene expression and development. In this issue of Genes & Development, Cohen and colleagues (pp. 354-366) use the developing mouse epidermis as a model system to show that the two central Polycomb repressive complexes, PRC1 and PRC2, have autonomous yet overlapping functions in repressing Polycomb target genes. They show that this cooperation enables the stable repression of nonepidermal transcription factors that would otherwise compromise epidermal cell identity and disrupt normal skin development.

Original publication

DOI

10.1101/gad.348257.121

Type

Journal article

Journal

Genes Dev

Publication Date

01/03/2021

Volume

35

Pages

301 - 303

Keywords

H2AK119ub, H3K27me3, PRC1, PRC2, Polycomb, epidermis, epigenetics, skin, stem cell