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Glucose-stimulated insulin release from rodent pancreatic B-cells is thought to be initiated by the closing of ATP-sensitive K+ channels in the plasma membrane as a consequence of glucose metabolism. We have identified an ATP-sensitive K+ channel in membrane patches excised from human B-cells which is similar to that found in rodent B-cells in conductance, kinetics, ATP sensitivity and its inhibition by sulphonylureas. In man, the ATP-sensitive K+ channel may also have a central role in glucose-stimulated insulin secretion and may be (linked to) the receptor for the hypoglycemic sulphonylureas.

Type

Journal article

Journal

FEBS Lett

Publication Date

04/05/1987

Volume

215

Pages

9 - 12

Keywords

Adenosine Triphosphate, Glucose, Humans, Insulin, Ion Channels, Islets of Langerhans, Tolbutamide