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The KATP channel provides a link between metabolism and electrical activity in numerous cell types. It can be reconstituted by coexpression of two subunits, a pore-forming inward rectifier K+ channel and a regulatory subunit, the sulfonylurea receptor. Site-directed mutagenesis of these subunits enables analysis of the complex regulation of KATP, channel activity by metabolism and therapeutic drugs.


Journal article


News in Physiological Sciences

Publication Date





255 - 262