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The L3/T4+ and Lyt-2+ T-cell subsets can be depleted from mice, using selected monoclonal antibodies in vivo, at different times during rejection of, or priming to, allogeneic skin grafts. Although L3/T4+ cells are sufficient to reject skin grafts in naive Lyt-2-depleted mice, we show that Lyt-2+ cells can become involved, after an initial delay, in intact mice. Furthermore, these Lyt-2+ cells are primed to dominate the accelerated rejection of a normal secondary response. Mice depleted of L3/T4+ cells cannot be primed in this way, suggesting that priming of Lyt-2+ cells is dependent on help from L3/T4+ cells. However, in mice depleted of Lyt-2+ cells, priming for rapid rejection can be achieved, presumably via the L3/T4+ population. This suggests that the rejection of skin allografts in a given situation reflects different contributions of multiple effector mechanisms.

Type

Journal article

Journal

Transplantation

Publication Date

05/1986

Volume

41

Pages

634 - 639

Keywords

Animals, Antibodies, Monoclonal, Antigens, Differentiation, T-Lymphocyte, Antigens, Ly, Antigens, Surface, Graft Rejection, Mice, Mice, Inbred Strains, Minor Histocompatibility Loci, Rats, Skin Transplantation, T-Lymphocytes, Thymectomy