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Accumulation of DNA damage in resting cells is an emerging cause of human disease. We identified a mechanism of DNA double-strand break (DSB) formation in non-replicating cells, which strictly depends on transcription. These transcriptional DSBs arise from the twinned processing of R-loops and topoisomerase I and may underlie neurological disorders and cancers.

Original publication

DOI

10.1080/23723556.2019.1691905

Type

Journal article

Journal

Mol Cell Oncol

Publication Date

2020

Volume

7

Keywords

Cancer, DNA double-strand break, DNA repair, Neurodegenerative disease, R-loop, RNA/DNA hybrid, Senataxin, TDP1, Topoisomerase I, Transcription, XPF