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The termination of transcription of eukaryotic genes by RNA polymerase II, at first sight, appears to be a rather random process, with the heterogeneous transcripts produced being processed to generate their correct 3' ends. However, recent studies have revealed that specific termination or pause sites may influence the process. The mechanism of termination may even play a role in eukaryotic gene regulation.


Journal article


Trends Biochem Sci

Publication Date





105 - 110


Eukaryotic Cells, RNA Polymerase II, Transcription, Genetic