Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The F-box DNA helicase Fbh1 constrains homologous recombination in vegetative cells, most likely through an ability to displace the Rad51 recombinase from DNA. Here, we provide the first evidence that Fbh1 also serves a vital meiotic role in fission yeast to promote normal chromosome segregation. In the absence of Fbh1, chromosomes remain entangled or segregate unevenly during meiosis, and genetic and cytological data suggest that this results in part from a failure to efficiently dismantle Rad51 nucleofilaments that form during meiotic double-strand break repair.

Original publication




Journal article


Nucleic Acids Res

Publication Date





1718 - 1731


Chromosome Segregation, DNA Breaks, Double-Stranded, DNA Helicases, DNA Repair, DNA, Fungal, DNA-Binding Proteins, F-Box Proteins, Gene Conversion, Gene Deletion, Meiosis, Nuclear Proteins, Rad51 Recombinase, Recombination, Genetic, Schizosaccharomyces, Schizosaccharomyces pombe Proteins, Spores, Fungal