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The F-box DNA helicase Fbh1 constrains homologous recombination in vegetative cells, most likely through an ability to displace the Rad51 recombinase from DNA. Here, we provide the first evidence that Fbh1 also serves a vital meiotic role in fission yeast to promote normal chromosome segregation. In the absence of Fbh1, chromosomes remain entangled or segregate unevenly during meiosis, and genetic and cytological data suggest that this results in part from a failure to efficiently dismantle Rad51 nucleofilaments that form during meiotic double-strand break repair.

Original publication

DOI

10.1093/nar/gkq977

Type

Journal article

Journal

Nucleic Acids Res

Publication Date

03/2011

Volume

39

Pages

1718 - 1731

Keywords

Chromosome Segregation, DNA Breaks, Double-Stranded, DNA Helicases, DNA Repair, DNA, Fungal, DNA-Binding Proteins, F-Box Proteins, Gene Conversion, Gene Deletion, Meiosis, Nuclear Proteins, Rad51 Recombinase, Recombination, Genetic, Schizosaccharomyces, Schizosaccharomyces pombe Proteins, Spores, Fungal