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Duchenne muscular dystrophy is caused by dystrophin deficiency, which can be prevented in the mdx mouse model by over-expression of an autosomal homologue, utrophin. Utrophin has two characterised full-length promoters, A and B. No data are available on the transcriptional regulation of B utrophin, which has been recently localised to the endothelium. Similar to characterised endothelial promoters, Ets and Ap-1 individually trans-activate the human B core promoter. Synergistic activation by GATA-2 and c-jun to the order of 20-fold was observed.


Journal article



Publication Date





168 - 172


Animals, Base Sequence, Cell Line, Cytoskeletal Proteins, Electrophoretic Mobility Shift Assay, Endothelium, Gene Expression Regulation, Humans, Membrane Proteins, Mice, Molecular Sequence Data, Promoter Regions, Genetic, Sequence Homology, Nucleic Acid, Tetradecanoylphorbol Acetate, Transcription Factors, Transcriptional Activation, Utrophin