Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Most models for transcription and replication involve polymerases that track along the template. We review here experiments that suggest an alternative in which polymerization occurs as the template slides past a polymerase fixed to a large structure in the eukaryotic nucleus—a “factory” attached to a nucleoskeleton. This means that higher-order structure dictates how and when DNA is replicated or transcribed. © 1995 Academic Press Inc.

Original publication

DOI

10.1016/S0074-7696(08)61230-9

Type

Journal article

Journal

International Review of Cytology

Publication Date

01/01/1996

Volume

162

Pages

125 - 149