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Gene transcription occurs on a nucleosomal template known as chromatin. The recruitment of the transcriptional regulators and the transcription machinery to promoter chromatin is coordinated by a genetic code on the DNA and an epigenetic code on the histone proteins. Chromatin is not a stable environment; rather, the histones, the transcription regulatory proteins and the enzymes that modify and mobilise nucleosomes are in a dynamic state. Thus, at any one time, the factors associated with a region will cooperate or compete to change the rate of inter-conversion between permissive and non-permissive chromatin states, leading to activation or repression of transcription. Here, new concepts such as dynamic nucleosomes and a dynamic histone code in gene transcription are explored.

Original publication

DOI

10.1016/j.tig.2006.03.008

Type

Journal article

Journal

Trends Genet

Publication Date

06/2006

Volume

22

Pages

320 - 329

Keywords

Acetylation, Amino Acid Sequence, Animals, Chromatin, Dimerization, Histone Deacetylases, Histones, Humans, Methylation, Molecular Sequence Data, Nucleosomes, Transcription, Genetic