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Isw1p and Isw2p are budding yeast homologs of the Drosophila ISWI chromatin-remodeling ATPase. Using indirect-end-label and chromatin immunoprecipitation analysis, we show both independent and cooperative Isw1p- and Isw2p-mediated positioning of short nucleosome arrays in gene-regulatory elements at a variety of transcription units in vivo. We present evidence that both yeast ISWI complexes regulate developmental responses to starvation and that for Isw2p, recruitment by different DNA-binding proteins controls meiosis and haploid invasive growth.

Original publication

DOI

10.1101/gad.190301

Type

Journal article

Journal

Genes Dev

Publication Date

01/03/2001

Volume

15

Pages

619 - 626

Keywords

Adenosine Triphosphatases, Blotting, Northern, Chromatin, DNA Footprinting, DNA, Fungal, Fungal Proteins, Meiosis, Micrococcal Nuclease, Nucleic Acid Hybridization, Saccharomyces cerevisiae, Transcription Factors