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Understanding the mechanisms that coordinate the orientation of cell division planes during embryogenesis and morphogenesis is a fundamental problem in developmental biology. Here we show that the orphan receptor lat-1, a homolog of vertebrate latrophilins, plays an essential role in the establishment of tissue polarity in the C. elegans embryo. We provide evidence that lat-1 is required for the alignment of cell division planes to the anterior-posterior axis and acts in parallel to known polarity and morphogenesis signals. lat-1 is a member of the Adhesion-GPCR protein family and is structurally related to flamingo/CELSR, an essential component of the planar cell polarity pathway. We dissect the molecular requirements of lat-1 signaling and implicate lat-1 in an anterior-posterior tissue polarity pathway in the premorphogenesis stage of C. elegans development.

Original publication

DOI

10.1016/j.devcel.2009.08.008

Type

Journal article

Journal

Dev Cell

Publication Date

10/2009

Volume

17

Pages

494 - 504

Keywords

Animals, Animals, Genetically Modified, Caenorhabditis elegans, Cell Division, Cell Polarity, Embryo, Nonmammalian, Embryonic Development, Gene Expression Regulation, Developmental, Immunoenzyme Techniques, In Situ Hybridization, Oogenesis, Organogenesis, RNA, Small Interfering, Receptors, Peptide, Signal Transduction, Spindle Apparatus