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The irreversibility of cell-cycle transitions is commonly thought to derive from the irreversible degradation of certain regulatory proteins. We argue that irreversible transitions in the cell cycle (or in any other molecular control system) cannot be attributed to a single molecule or reaction, but that they derive from feedback signals in reaction networks. This systems-level view of irreversibility is supported by many experimental observations.

Original publication

DOI

10.1038/ncb0707-724

Type

Journal article

Journal

Nat Cell Biol

Publication Date

07/2007

Volume

9

Pages

724 - 728

Keywords

Animals, Cell Cycle, Cell Cycle Proteins, Cell Division, DNA Replication, Feedback, Physiological, Humans, Models, Biological