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Proteins of the CcdA/DsbD family have previously been found to be involved in the protein disulfide isomerase and cytochrome c maturation pathways of bacteria. SoxV is a CcdA homologue encoded by a genetic locus involved in lithotrophic thiosulfate oxidation in Rhodovulum sulfidophilum. Mutagenesis studies demonstrate an essential and specific role for SoxV in thiosulfate oxidation. Another protein encoded by the same locus, SoxW, is a periplasmic thioredoxin. SoxW was found to be in the reduced state during growth of R. sulfidophilum in the presence of thiosulfate. Maintenance of SoxW in the reduced state was shown to require SoxV. Nevertheless, SoxW was found to be dispensible for thiosulfate oxidation suggesting that SoxV reduces more than one periplasmic partner protein.

Type

Journal article

Journal

Biochem Biophys Res Commun

Publication Date

23/08/2002

Volume

296

Pages

737 - 741

Keywords

Alphaproteobacteria, Bacterial Proteins, Cell Membrane, Disulfides, Membrane Transport Proteins, Multigene Family, Oxidation-Reduction, Oxidoreductases, Thioredoxin-Disulfide Reductase, Thioredoxins, Thiosulfates