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FANCM and its relatives, Hef, Mph1 and Fml1, are DNA junction-specific helicases/translocases that target and process perturbed replication forks and intermediates of homologous recombination. They have variously been implicated in promoting the activation of the S-phase checkpoint, recruitment of the Fanconi Anemia Core Complex to sites of DNA damage, crossover avoidance during DNA double-strand break repair by homologous recombination, and the replicative bypass of DNA lesions by template switching. This review summarises our current understanding of the biochemical activities and biological functions of the FANCM family.

Original publication

DOI

10.1016/j.dnarep.2009.12.012

Type

Journal article

Journal

DNA Repair (Amst)

Publication Date

02/03/2010

Volume

9

Pages

224 - 236

Keywords

Animals, DNA, DNA Helicases, DNA Repair, DNA Replication, Humans, Protein Binding