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Recent structural studies show, not only how the desensitization of a ligand-gated ion channel with bound agonist can be rationalized in terms of subunit-subunit instability, but also how a previously unknown mode of interaction may provide clues into how the receptor is tetramerically assembled in vivo.

Type

Journal article

Journal

Curr Biol

Publication Date

17/09/2002

Volume

12

Pages

R631 - R632

Keywords

Animals, Binding Sites, Dimerization, Models, Molecular, Protein Structure, Quaternary, Receptors, Glutamate