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Histone methylation has important roles in regulating gene expression and forms part of the epigenetic memory system that regulates cell fate and identity. Enzymes that directly remove methyl marks from histones have recently been identified, revealing a new level of plasticity within this epigenetic modification system. Here we analyse the evolutionary relationship between Jumonji C (JmjC)-domain-containing proteins and discuss their cellular functions in relation to their potential enzymatic activities.

Original publication

DOI

10.1038/nrg1945

Type

Journal article

Journal

Nat Rev Genet

Publication Date

09/2006

Volume

7

Pages

715 - 727

Keywords

Amino Acid Motifs, Amino Acid Sequence, Animals, Epigenesis, Genetic, Gene Expression Regulation, Histone-Lysine N-Methyltransferase, Histones, Humans, Molecular Sequence Data, Nuclear Proteins, Oxidoreductases, N-Demethylating, Phylogeny, Protein Methyltransferases, Protein Structure, Tertiary, Sequence Alignment, Transcription, Genetic