Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Histone methylation has important roles in regulating gene expression and forms part of the epigenetic memory system that regulates cell fate and identity. Enzymes that directly remove methyl marks from histones have recently been identified, revealing a new level of plasticity within this epigenetic modification system. Here we analyse the evolutionary relationship between Jumonji C (JmjC)-domain-containing proteins and discuss their cellular functions in relation to their potential enzymatic activities.

Original publication




Journal article


Nat Rev Genet

Publication Date





715 - 727


Amino Acid Motifs, Amino Acid Sequence, Animals, Epigenesis, Genetic, Gene Expression Regulation, Histone-Lysine N-Methyltransferase, Histones, Humans, Molecular Sequence Data, Nuclear Proteins, Oxidoreductases, N-Demethylating, Phylogeny, Protein Methyltransferases, Protein Structure, Tertiary, Sequence Alignment, Transcription, Genetic