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2B is a 99 amino acid membrane protein encoded by enteroviruses such as polio and coxsackie viruses with two transmembrane domains. The protein is found to make membranes of infected cells permeable. Using a computational approach which positions the models and assesses stability by molecular dynamics (MD) simulations a putative tetrameric bundle model of 2B is generated. The bundles show a pore lining motif of three lysines followed by a serine. The bundle is discussed in terms of different possible orientations of the helices in the membrane and the consequences this has on the in vivo activity of 2B.

Original publication

DOI

10.1080/09687680903164101

Type

Journal article

Journal

Mol Membr Biol

Publication Date

08/2009

Volume

26

Pages

309 - 320

Keywords

Amino Acid Sequence, Computational Biology, Computer Simulation, Enterovirus, Ion Channels, Lysine, Models, Molecular, Molecular Sequence Data, Poliovirus, Protein Multimerization, Protein Structure, Secondary, Protein Structure, Tertiary, Static Electricity, Viral Nonstructural Proteins, Viral Proteins