Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

During early development in female mammals, most genes on one of the two X-chromosomes undergo transcriptional silencing. In the extraembryonic lineages of some eutherian species, imprinted X-inactivation of the paternal X-chromosome occurs. In the cells of the embryo proper, the choice of the future inactive X-chromosome is random. We mapped several genes on the X-chromosomes of five common vole species and compared their expression and methylation patterns in somatic and extraembryonic tissues, where random and imprinted X-inactivation occurs, respectively. In extraembryonic tissues, more genes were expressed on the inactive X-chromosome than in somatic tissues. We also found that the methylation status of the X-linked genes was always in accordance with their expression pattern in somatic, but not in extraembryonic tissues. The data provide new evidence that imprinted X-inactivation is less complete and/or stable than the random form and DNA methylation contributes less to its maintenance.

Original publication

DOI

10.1007/s00412-010-0277-6

Type

Journal article

Journal

Chromosoma

Publication Date

10/2010

Volume

119

Pages

541 - 552

Keywords

Animals, Arvicolinae, Chromosome Mapping, DNA Methylation, Female, Gene Expression, Genes, X-Linked, Genomic Imprinting, Humans, In Situ Hybridization, Fluorescence, Male, Muridae, RNA, Long Noncoding, RNA, Untranslated, Repressor Proteins, X Chromosome, X Chromosome Inactivation