Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

A team of NDCN neuroimaging researchers will lead this study, which has received a grant from the University of Oxford's COVID-19 Research Response Fund.

COVID-19 adversely affects the brain. Around 36 per cent of hospitalised patients show symptoms ranging from loss of sense of smell, to strokes, and seizures. Concerns are growing that COVID-19 may cause long-term harmful neurological effects including cognitive impairment, mental health disorders, and chronic breathing difficulties. This may arise from the direct viral invasion of the brain, or autoimmune responses to the infection, or indirect effects of severe systemic illness.

Using magnetic resonance imaging (MRI), a team led by Associate Professor Kyle Pattinson will quantify brain abnormalities associated with COVID-19 infection. Their aim is to collect proof-of-concept data that will leverage funding for further multi-centre research collaborations. The eventual outcome will be brain markers to direct individualised treatments improving both short- and long-term outcomes from COVID-19.

The team will undertake two observational studies: an acute study in hospitalised patients and a follow-up study, using high-resolution brain-stem MRI, performed 3-6 months later, after patients have been discharged from hospital. In this way, the researchers will be able to characterise the brain structural, functional, and cerebrovascular effects of COVID-19 infection, establish quantitative relationships between clinical/bedside measures of COVID-19 and neuroimaging measures, and provide preliminary data sets for future discovery of novel biomarkers.

Similar stories

Healthy Start, Happy Start Study

Research Highlights

Healthy Start, Happy start is a randomised controlled trial that tested the clinical- and cost-effectiveness of a brief parenting programme - Video-feedback Intervention to promote Positive Parenting and Sensitive Discipline (VIPP-SD).

New Way of Understanding Dissociation Could Improve Patient Care

Research Highlights

New research has developed a novel measure of dissociative experiences that share a subjective 'felt sense of anomaly'. This new approach could revolutionise how clinicians understand dissociative experiences across a range of mental health disorders, and how they work with patients with dissociation in the future.

New Analysis Challenges Guidelines on Treating Anorexia Nervosa

Research Highlights

A new analysis, published in The Lancet Psychiatry, has shown a lack of strong evidence to support current guidance on psychological therapies for treating anorexia nervosa over expert treatment as usual.

Capturing immune cells that colonise the brain to prevent disease progression in multiple sclerosis

Research Highlights

Researchers have revealed a disease-causing population of immune cells, which travel to the brain in patients with multiple sclerosis. They demonstrate how to trap these cells in the blood, which means they can be targeted to prevent disease progression.

How the brain reorganises old memories when new ones are made

Research Highlights

Researchers have discovered that the arrangement of existing memories in the brain is altered when we embed new memories