Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Results from an insight review commissioned by the Wellcome Trust, highlights what is currently known about the benefits and risks of using selective serotonin reuptake inhibitors (SSRIs) for the treatment of depression and anxiety in young people.

One of a series of Wellcome Trust reviews of the active ingredients of interventions to prevent/treat depression and anxiety in young people was carried out by the team in the Psychopharmacology and Emotion Research Laboratory (PERL) at the Department of Psychiatry, University of Oxford. They reviewed the literature about the use of antidepressants in young people aged 14-24 years, and held a series of online workshops with young people with lived experience, which were supported by the McPin Foundation and the NEUROSEC (Neuroscience, Ethics and Society) Young People Advisory Group. 

Dr Susie Murphy, Department of Psychiatry, said,

There is understandable disquiet about the use of antidepressants in young people and yet there are also significant risks associated with under-treating severe depression in this age group. It is important to understand the effects antidepressants have in young people so that they can make informed choices about the best treatment approach for them. 

A recent blog - Antidepressants and psychotherapy for adolescent depression: can they be compared? #ActiveIngredientsMH.

A new animation created with contributions from young people with lived experience from the McPin Foundation and NEUROSEC - Antidepressants for young people with depression and anxiety.

 

 

Listen to a podcast with Professor Catherine Harmer and Dr Susie Murphy discussing the knowns and unknowns of antidepressant effects in young people with the Mental Elf.

For more information about the work of PERL.

Similar stories

Healthy Start, Happy Start Study

Research Highlights

Healthy Start, Happy start is a randomised controlled trial that tested the clinical- and cost-effectiveness of a brief parenting programme - Video-feedback Intervention to promote Positive Parenting and Sensitive Discipline (VIPP-SD).

New Way of Understanding Dissociation Could Improve Patient Care

Research Highlights

New research has developed a novel measure of dissociative experiences that share a subjective 'felt sense of anomaly'. This new approach could revolutionise how clinicians understand dissociative experiences across a range of mental health disorders, and how they work with patients with dissociation in the future.

New Analysis Challenges Guidelines on Treating Anorexia Nervosa

Research Highlights

A new analysis, published in The Lancet Psychiatry, has shown a lack of strong evidence to support current guidance on psychological therapies for treating anorexia nervosa over expert treatment as usual.

Capturing immune cells that colonise the brain to prevent disease progression in multiple sclerosis

Research Highlights

Researchers have revealed a disease-causing population of immune cells, which travel to the brain in patients with multiple sclerosis. They demonstrate how to trap these cells in the blood, which means they can be targeted to prevent disease progression.

How the brain reorganises old memories when new ones are made

Research Highlights

Researchers have discovered that the arrangement of existing memories in the brain is altered when we embed new memories