Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

One in three COVID-19 survivors received a neurological or psychiatric diagnosis within six months of infection with the SARS-CoV-2 virus.

The study looked at 14 neurological and mental health disorders.

Professor Paul Harrison, lead author of the study, from the Department of Psychiatry at Oxford University, said: “These are real-world data from a large number of patients. They confirm the high rates of psychiatric diagnoses after COVID-19, and show that serious disorders affecting the nervous system (such as stroke and dementia) occur too. While the latter are much rarer, they are significant, especially in those who had severe COVID-19.

“Although the individual risks for most disorders are small, the effect across the whole population may be substantial for health and social care systems due to the scale of the pandemic and that many of these conditions are chronic. As a result, health care systems need to be resourced to deal with the anticipated need, both within primary and secondary care services.”

Since the COVID-19 pandemic began, there has been growing concern that survivors might be at increased risk of neurological disorders. A previous observational study by the same research group reported that COVID-19 survivors are at increased risk of mood and anxiety disorders in the first three months after infection. However, until now, there have been no large-scale data examining the risks of neurological as well as psychiatric diagnoses in the six months after COVID-19 infection.

This latest study analysed data from the electronic health records of 236,379 COVID-19 patients from the US-based TriNetX network, which includes more than 81 million people. This group was compared with 105,579 patients diagnosed with influenza and 236,038 patients diagnosed with any respiratory tract infection (including influenza).

Overall, the estimated incidence of being diagnosed with a neurological or mental health disorder following COVID-19 infection was 34%. For 13% of these people it was their first recorded neurological or psychiatric diagnosis.

The most common diagnoses after COVID-19 were anxiety disorders (occurring in 17% of patients), mood disorders (14%), substance misuse disorders (7%), and insomnia (5%). The incidence of neurological outcomes was lower, including 0.6% for brain haemorrhage, 2.1% for ischaemic stroke, and 0.7% for dementia.

After taking into account underlying health characteristics, such as age, sex, ethnicity and existing health conditions, there was overall a 44% greater risk of neurological and mental health diagnoses after COVID-19 than after flu, and a 16% greater risk after COVID-19 than with respiratory tract infections.

Dr Max Taquet, a co-author of the study from Oxford University, said: “Our results indicate that brain diseases and psychiatric disorders are more common after COVID-19 than after flu or other respiratory infections, even when patients are matched for other risk factors. We now need to see what happens beyond six months. The study cannot reveal the mechanisms involved, but does point to the need for urgent research to identify these, with a view to preventing or treating them.”

Read the full paper in The Lancet Psychiatry.

The study was funded by the National Institute for Health Research (NIHR) Oxford Health Biomedical Research Centre.

Similar stories

Being "in the zone": how waking activity controls sleep need

Research Highlights

A new study from the Vyazovskiy group suggests that how and where we spend our time while awake impacts how much we need to sleep - it does not only depend on how long we are awake.

No Evidence of Increased Risk of Suicide in First Months of Pandemic

Research Highlights

A new observational study is the first to examine suicides occurring during the early phase of the COVID-19 pandemic in multiple countries and finds that suicide numbers largely remained unchanged or declined.

New research to radically alter our understanding of synaptic development

Research Highlights

A new study from the Molnár group on the role of regulated synaptic vesicular release in specialised synapse formation has made it to the cover of Cerebral Cortex.

Healthy Start, Happy Start Study

Research Highlights

Healthy Start, Happy start is a randomised controlled trial that tested the clinical- and cost-effectiveness of a brief parenting programme - Video-feedback Intervention to promote Positive Parenting and Sensitive Discipline (VIPP-SD).

New Way of Understanding Dissociation Could Improve Patient Care

Research Highlights

New research has developed a novel measure of dissociative experiences that share a subjective 'felt sense of anomaly'. This new approach could revolutionise how clinicians understand dissociative experiences across a range of mental health disorders, and how they work with patients with dissociation in the future.