Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

A partnership between University of Oxford, the Earlham Institute, and the global pharmaceutical companies Biogen Inc and Boehringer Ingelheim has been announced to investigate a new drug target for the treatment of schizophrenia.

This is the first project to be funded by the international Psychiatry Consortium, a £4 million collaboration between seven global pharmaceutical companies, and two leading research charities, convened and managed by the Medicines Discovery Catapult, that supports high-value drug discovery projects in this area of unmet patient need.

The world-leading team of academic researchers will use their newly designed technical approach to assess which proteins are selectively produced by the kalirin gene in the human brain, and how this differs from other human tissues.

Once this is understood it may be possible to identify the proteins that represent the most promising drug targets for the potential treatment of schizophrenia, how they affect the function of cells, and begin to develop drugs to alter their function.

Liz Tunbridge, Associate Professor in the Department of Psychiatry at the University of Oxford, and lead investigator for the study, commented,

 
“We desperately need new treatments for schizophrenia because current drugs can cause side effects, do not work for everyone and do not improve all the symptoms. However, it has been difficult to improve this situation because of our limited understanding of the changes in the brain that underlie schizophrenia. This exciting collaboration will enable us to start the long journey from genetic research to the development of new drugs. Ultimately, we hope that our research will one day lead to new medicines that improve the lives of people with schizophrenia.”

Dr. Hugh Marston, Head of Department CNS Diseases Research at Boehringer Ingelheim, said,

“Schizophrenia is a serious mental health condition that alters a person’s perception of reality, impacts how they think, feel, and behave. Current treatment options leave significant room for improvement through the development of new therapeutics. We recognize the importance of finding new solutions for people living with neuropsychiatric disorders with our innovative CNS research program as a key focus area at Boehringer Ingelheim. As this program focuses on improving our understanding of the mechanisms that underly these complex disorders, we are pleased to be part of this first research project of the Psychiatry Consortium. We hope a successful completion will make a real impact on the development of innovative treatment options.”

Diana Gallagher, Head of External Innovation, Biogen, said, 

“At Biogen we recognise the enormous impact psychiatric disorders have on mental health. The significant gap in treatment options leaves many with poor long-term quality of life and disability. Being part of the Medicines Discovery Catapult (MDC) Psychiatry Consortium, builds on Biogen’s recent licensing and partnership of later-stage drug candidates for psychiatry, and participation in this project, and its successful outcome, could inform our thinking on neuropsychiatric disorders where Biogen will aim to develop new treatments for patients.”

Professor Chris Molloy, Chief Executive Officer at Medicines Discovery Catapult (MDC), said, 

“At a time when mental health research is gravely underfunded, this group of academic and industrial scientists, brought together in the Psychiatry Consortium by Medicines Discovery Catapult, is delivering improved understanding of schizophrenia in ways that can be directly applied to new drug discovery.

“This is a landmark for the Psychiatry Consortium – one of many to follow - intended to yield tangible improvements for those living with schizophrenia.”

Similar stories

New Research Highlights Importance of Early Years Development on Future Wellbeing

Oxford researchers involved nearly 4,000 children across the UK in three specially developed science lessons to educate pupils about brain development during early childhood. The SEEN (Secondary Education around Early Neurodevelopment) project was commissioned and funded by KindredSquared and is part of a wider drive to increase public understanding of how early experiences can shape the adults we become.

Evaluating risk to people with epilepsy during the COVID-19 pandemic - study wins international prize

In May 2020 our researchers initiated a global project to investigate how COVID-19 has affected people with epilepsy, their carers and health care workers.

Oxfordshire Young People Involved in Childline Research Project

New research conducted by the Neuroscience, Ethics and Society group and NeurOX Young People’s Advisory Group in the Department of Psychiatry at the University of Oxford, and the NSPCC, has looked at how Childline’s message boards help support young people.

New European initiative to accelerate the discovery and validation of biomarkers for neurodegenerative diseases

Members of the European Platform for Neurodegenerative Diseases (EPND) will establish a collaborative platform for efficient sample and data sharing, linking existing European research infrastructures to accelerate the discovery of biomarkers, new diagnostics and treatments for the benefit of people with neurodegenerative diseases such as Alzheimer's and Parkinson's.