Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

This new study using Canadian and Swiss data showed that the risk calculator used to predict the likelihood of developing a major mood disorder was correct approximately 70% of the time. The study results suggest this may be a useful clinical tool in routine practice for improved individualised risk estimation of bipolar spectrum disorders among the adolescent offspring of a parent with a bipolar disorder.

Family history is a significant risk factor for bipolar disorders, but the magnitude of risk varies considerably between individuals within and across families.

The study summarises the development and independent replication of a digitalised personal risk calculator to tailor the individual risk of developing a mood disorder in 5 to 10 years for a young person with a confirmed first degree relative (i.e. parent) with a diagnosis of bipolar disorder.  Data is based on two independent high-risk offspring of bipolar parent studies over two decades in Canada and Switzerland.

Visiting Professor Anne Duffy, co-author, Department of Psychiatry, University of Oxford, said:

 

'The risk calculator that we have developed is a tool meant to assist clinicians with identifying those young people who might benefit from closer monitoring and to motivate healthy lifestyle choices, and the reduction of modifiable risk factors, such as sleep regulation, substance use and exercise.'

To read the full study, published in The Lancet - EClinicalMedicince, Development and validation of a risk calculator for major mood disorders among the offspring of bipolar parents using information collected in routine clinical practice.

The study is funded by a grant from the Canadian Institutes of Health Research.

Similar stories

New Research Highlights Importance of Early Years Development on Future Wellbeing

Oxford researchers involved nearly 4,000 children across the UK in three specially developed science lessons to educate pupils about brain development during early childhood. The SEEN (Secondary Education around Early Neurodevelopment) project was commissioned and funded by KindredSquared and is part of a wider drive to increase public understanding of how early experiences can shape the adults we become.

Evaluating risk to people with epilepsy during the COVID-19 pandemic - study wins international prize

In May 2020 our researchers initiated a global project to investigate how COVID-19 has affected people with epilepsy, their carers and health care workers.

Oxfordshire Young People Involved in Childline Research Project

New research conducted by the Neuroscience, Ethics and Society group and NeurOX Young People’s Advisory Group in the Department of Psychiatry at the University of Oxford, and the NSPCC, has looked at how Childline’s message boards help support young people.

New European initiative to accelerate the discovery and validation of biomarkers for neurodegenerative diseases

Members of the European Platform for Neurodegenerative Diseases (EPND) will establish a collaborative platform for efficient sample and data sharing, linking existing European research infrastructures to accelerate the discovery of biomarkers, new diagnostics and treatments for the benefit of people with neurodegenerative diseases such as Alzheimer's and Parkinson's.

PTSD in healthcare workers during pandemic could be exacerbated by past trauma

While some of the high rates of post-traumatic stress (PTSD) seen in healthcare workers during the pandemic are specifically COVID-19-related, a more significant number of cases were linked to trauma that occurred earlier in their lives, researchers at the University of Oxford have found.