Our Alzheimer’s disease research aims to cross the divide between basic genomic research, translational research, prevention and clinical care. Our research spans:
- Genetic research has been an important pillar of our understanding of the molecular pathology of Alzheimer’s disease.
- Our research is based on big data analysis aiming to discover new genetic variants, and determine their functional effects using induced pluripotent stem cells, iPSCs.
- We study biomarkers and their clinical implications using multi-omics studies at the Big Data Institute (BDI) and Nuffield Dept of Population Health (NDPH).
From genes to medication
- The Alzheimer’s Research UK Oxford Drug Discovery Institute (ODDI) bridges the gap between molecular mechanisms underlying Alzheimer disease and development of innovative drugs.
- The center combines state of art drug discovery expertise with that of researchers from Genetics, Biology, Chemistry, Psychiatry, and Neuroscience.
Cognition and Neuroimaging
- Our expertise in brain imaging at the Wellcome Centre for Integrative Neuroimaging (WIN) has led to novel methods to analyse brain structure and function and how these are disrupted in Alzheimer’s disease.
- We have developed new, sensitive ways to measure memory in people with Alzheimer’s (Cognitive Neurology).
Cohorts and epidemiology
- We host various cohorts that have made major contribution to our understanding of the risk factors for Alzheimer’s disease such as the Million Women Study, Dementia Platforms UK, UKBiobank and the OPTIMA study.
- We aim to improve prevention of Alzheimer’s by disentangling the causes and consequences of disease and are studying new frontiers in epidemiology including the microbiome (BDI).
- Our expertise in big data analysis spans machine learning, digital phenotyping and neuroimaging.
Clinical and patient-focused research
- We are part of the Oxford NIHR Biomedical Research Centre (Oxford BRC) and the Oxford Health HIHR Biomedical Research Centre (Oxford Health BRC).
- Our team at the Dept of Psychiatry are leading figures in European Prevention of Alzheimer’s Dementia (EPAD) longitudinal cohort study, deep and Frequent Phenotyping (DFP) and MIcroglial CSF1R in Alzheimer’s Disease (MICAD) studies. They are conducting experimental research on biomarkers and leading clinical trials in dementia.
- Our Cognitive Disorders Clinic at the John Radcliffe Hospital, Brain Health Centre at the Warneford Hospital and memory clinic services provide high-quality assessments for patients, integrating research into clinical services.