Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

It is no longer tenable to view schizophrenia as a 'functional' disorder, lacking any structural involvement of the brain. There is a neuropathology, albeit one about which our understanding is still rudimentary, and which is far from allowing schizophrenia to be diagnosable from a brain scan or down a microscope. Both neurons and glia are affected. Changes are prominent in, but not limited to, the prefrontal cortex and hippocampus. The neuropathology is likely to represent and reflect an altered connectivity and circuitry, caused at least partly by the susceptibility genes and mediated through a perturbation of brain development and synaptic plasticity. © 2008 Elsevier Ltd. All rights reserved.

Original publication

DOI

10.1016/j.mppsy.2008.07.013

Type

Journal article

Journal

Psychiatry

Publication Date

01/10/2008

Volume

7

Pages

421 - 424