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BACKGROUND: Administration of a complex tyrosine-free amino acid drink acutely decreases manic symptoms. Although a nutrient-based approach to illness management is attractive, complex amino acid drinks are too unpalatable for repeated administration. AIMS: To assess whether a simple, branched-chain amino acid (BCAA) drink diminishes manic symptoms acutely and following repeated administration. METHOD: Twenty-five patients with mania were randomly and blindly allocated to treatment with BCAA (60 g) or placebo daily for 7 days. RESULTS: Relative to placebo, the BCAA drink lowered mania ratings acutely over the first 6 h of treatment. In protocol completers there was a persistent advantage to the BCAA group 1 week after the end of treatment. CONCLUSIONS: A nutritional intervention that decreases tyrosine availability to the brain acutely ameliorates manic symptoms. Further studies are required to assess whether this approach has longer-term efficacy.

Type

Journal article

Journal

Br J Psychiatry

Publication Date

03/2003

Volume

182

Pages

210 - 213

Keywords

Adult, Amino Acids, Branched-Chain, Analysis of Variance, Beverages, Bipolar Disorder, Humans, Isoleucine, Leucine, Middle Aged, Placebo Effect, Psychiatric Status Rating Scales, Tyrosine, Valine