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An effective immune system depends upon regulation of lymphocyte function and homeostasis. In recent years, members of the GTPases of the immunity associated protein (GIMAP) family were proposed to regulate T cell homeostasis. In contrast, little is known about their function and mode of action in B cells. We used a combination of transgenic mice and in vivo and in vitro techniques to conditionally and electively ablate GIMAP1 in resting and activated peripheral B cells. Our data suggest that GIMAP1 is absolutely essential for the survival of peripheral B cells, irrespective of their activation state. Together with recent data showing increased expression of GIMAP1 in B cell lymphomas, our work points to the possible potential of GIMAP1 as a target for manipulation in a variety of B cell-mediated diseases.

Original publication

DOI

10.4049/jimmunol.1501582

Type

Journal article

Journal

J Immunol

Publication Date

01/01/2016

Volume

196

Pages

207 - 216

Keywords

Animals, B-Lymphocytes, Cell Survival, Cells, Cultured, GTP-Binding Proteins, Germinal Center, Lymphocyte Activation, Lymphoma, B-Cell, Membrane Proteins, Mice, Mice, Transgenic