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The production of new myelin has been highlighted as an underappreciated mechanism of brain plasticity, but whether plastic decreases in myelin also happen in the adult brain has been largely unexplored. Recently, Sinclair et al. (Sinclair JS, Fischl MJ, Alexandrova O, Heß M, Grothe B, Leibold C, and Kopp-Scheinpflug C. J Neurosci 37: 8239-8255, 2017) have shown that auditory deprivation can lead to decrease in myelination and axon caliber even in healthy adulthood. These findings show that activity-regulated myelination is more complex than previously thought and expand our knowledge of how adult brain plasticity could operate on a cellular level.

Original publication

DOI

10.1152/jn.00070.2018

Type

Journal article

Journal

J Neurophysiol

Publication Date

01/10/2018

Volume

120

Pages

1772 - 1775

Keywords

auditory processing, conduction velocity, myelination, plasticity, sensory deprivation