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In Drosophila, the posterior localization of oskar mRNA and its translational regulation are essential for axis specification and germline formation. Recently in Cell, demonstrated that Bruno inhibits cap-dependent translation of oskar mRNA and uncovered a novel Bruno-dependent assembly of oskar mRNA into multimeric RNP particles, which are inaccessible to the translational machinery. This work provides a novel link between mRNA localization, particle formation, and translational regulation.

Original publication

DOI

10.1016/j.devcel.2006.02.001

Type

Journal article

Journal

Dev Cell

Publication Date

03/2006

Volume

10

Pages

280 - 281

Keywords

Animals, Drosophila Proteins, Drosophila melanogaster, Gene Silencing, Protein Biosynthesis, RNA, Messenger, RNA-Binding Proteins