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Regulatory T cells are important for ensuring that the immune system does not attack self and does not overreact to external antigens. Understanding how these cells develop and maintain stable function provides general insights into cellular differentiation in general, as well as new opportunities for therapeutic manipulation.

Original publication

DOI

10.1016/j.immuni.2009.04.007

Type

Journal article

Journal

Immunity

Publication Date

05/2009

Volume

30

Pages

613 - 615

Keywords

Animals, Forkhead Transcription Factors, Graft Rejection, T-Lymphocytes, Regulatory, Transplantation Tolerance