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The genomes of influenza viruses consist of multiple segments of single-stranded negative-sense RNA. Each of these segments is bound by the heterotrimeric viral RNA-dependent RNA polymerase and multiple copies of nucleoprotein, which form viral ribonucleoprotein (vRNP) complexes. It is in the context of these vRNPs that the viral RNA polymerase carries out transcription of viral genes and replication of the viral RNA genome. In this Review, we discuss our current knowledge of the structure of the influenza virus RNA polymerase, and insights that have been gained into the molecular mechanisms of viral transcription and replication, and their regulation by viral and host factors. Furthermore, we discuss how advances in our understanding of the structure and function of polymerases could help in identifying new antiviral targets.

Original publication

DOI

10.1038/nrmicro.2016.87

Type

Journal article

Journal

Nat Rev Microbiol

Publication Date

08/2016

Volume

14

Pages

479 - 493

Keywords

Genome, Viral, Host-Pathogen Interactions, Humans, Influenza A virus, Influenza B virus, Models, Molecular, Orthomyxoviridae, Protein Conformation, RNA Replicase, RNA, Viral, Ribonucleoproteins, Viral Proteins, Virion, Virus Replication