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Cytoarchitectural abnormalities have been reported in the cortex in schizophrenia. These suggest a developmental origin for this disorder. The Wnt signalling pathway is involved in the regulation of brain development; disruption of this pathway may lead to abnormal cortical development. In this study levels of three components of the Wnt signalling pathway; glycogen synthase kinase-3beta(GSK-3beta), beta-catenin and dishevelled-2 (Dvl-2) were determined in the prefrontal cortex of ten schizophrenic and ten control individuals using immunoblotting. GSK-3beta levels were significantly reduced in the schizophrenic group, while levels of beta-catenin and Dvl-2 did not differ between groups. This provides further evidence for an abnormality of the Wnt signalling pathway in schizophrenia.

Type

Journal article

Journal

Neurosci Lett

Publication Date

20/04/2001

Volume

302

Pages

117 - 120

Keywords

Adaptor Proteins, Signal Transducing, Adult, Aged, Aged, 80 and over, Calcium-Calmodulin-Dependent Protein Kinases, Cytoskeletal Proteins, Dishevelled Proteins, Female, Glycogen Synthase Kinase 3, Glycogen Synthase Kinases, Humans, Immunohistochemistry, Male, Middle Aged, Phosphoproteins, Prefrontal Cortex, Proto-Oncogene Proteins, Schizophrenia, Signal Transduction, Trans-Activators, Wnt Proteins, Zebrafish Proteins, beta Catenin