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A combined crystal-structure determination and NMR analysis of the octanucleotide d(ATGCGCAT)2 is reported. The X-ray analysis shows that the structure is A-form duplex in crystal state. The NMR study shows that in solution this sequence is B-type. The conformational results from each technique are presented in detail. The implications of these findings in terms of conformational flexibility and ligand binding are discussed.

Original publication

DOI

10.1093/nar/18.18.5521

Type

Journal article

Journal

Nucleic Acids Res

Publication Date

25/09/1990

Volume

18

Pages

5521 - 5528

Keywords

Base Sequence, Magnetic Resonance Spectroscopy, Molecular Sequence Data, Nucleic Acid Conformation, Oligodeoxyribonucleotides, Solutions, X-Ray Diffraction