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Early demonstrations that mice could be tolerized to transplanted tissues with short courses of immunosuppressive therapy and that with regard to tolerance to self, CD4+FOXP3+ regulatory T cells (Tregs) appeared to play a critical role, have catalyzed strategies to harness FOXP3-dependent processes to control rejection in human transplantation. This review seeks to examine the scientific underpinning for this new approach to finesse immunosuppression.

Original publication

DOI

10.1172/JCI67226

Type

Journal article

Journal

J Clin Invest

Publication Date

04/2014

Volume

124

Pages

1439 - 1445

Keywords

Animals, Epigenesis, Genetic, Forkhead Transcription Factors, Humans, Immunosuppression, Mice, Receptors, Antigen, T-Cell, Signal Transduction, T-Lymphocytes, Regulatory, Transplantation Tolerance