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The pharmaceutical industry is reliant on a constant supply of new chemical entities and molecular targets for disease intervention. In this tutorial review, we want to illustrate that basic research studies on the biological function of natural products involved in plant-pathogen interactions can serve as an inspiring source for the identification of new bioactive entities as well as of strategies on how to achieve small molecule manipulation of biological systems. An application of findings from plant-pathogen interaction studies might therefore display a significant impact on drug discovery.

Original publication

DOI

10.1039/c2cs15301g

Type

Journal article

Journal

Chem Soc Rev

Publication Date

21/04/2012

Volume

41

Pages

3168 - 3178

Keywords

Biological Products, Biomimetics, Drug Discovery, Host-Pathogen Interactions, Humans, Plant Diseases, Plant Immunity, Plants, Small Molecule Libraries